Remove K+ from the patient. The crystals are covered with a layer of dextran. Heparin. After a dose of .1mmol/kg body weight, an average plasma level of 0.59 mmol/L was measured 2 minutes post injection, and 0.3mmol/L 60 minutes post injection. Concentration at the end of the dosing interval just before the next dose (within ~ 30-min of next dose). Oxaliplatin 130 mg/m2 IV Day 1 every 3 weeks + Capecitabine 1000 mg/m2 BID by mouth days 1-14 every 3 weeks for 4 cycles 117-96-4 - YVPYQUNUQOZFHG-UHFFFAOYSA-N - Diatrizoic acid [USAN:USP] - Similar structures search, synonyms, formulas, resource links, and other chemical information. The patients were divided into groups: a body weight (BW) group (n = 45) and a BSA (n = 44) group. Materials and methods A total of 104 patients weighing 40-80 kg (mean 58+/-9.7 kg) underwent contrast enhanced abdominal CT. Dose recommendations in terms of BSA are available only for a limited number of drugs (e.g., anticancer drugs) as this method . The authors hypothesized a relationship between the contrast dose, the body weight and the baseline kidney . Ped 5: Chest CT (without contrast, or with contrast) Indications: lung, mediastinal and pleural pathology. [54138] For patients with congenital adrenal hyperplasia (CAH), 2 mg/kg/dose IV at induction of anesthesia with repeat doses every 4 hours or as a continuous IV infusion . Although the intravenous route of administration is most common, they are also administered by many other routes, including gastrointestinal (oral . 22 With so many different options, the busulfan dosing regimen and target systemic exposure will vary according to the protocol and the treatment center. Metabolism. The vial of Lasix® contains 100 mg per 10 mL. 2) Then we can multiply the weight in kilograms by the dosage ordered/hr to get the required dose/hr In this case: 20kg x 5mg/kg/hr = 100 mg/hr. Iopamidol, expressed as a percentage of administered intravenous dose is approximately 35 to . Reported Dose (Normalized Dose) Effect Source; mouse: LD50: intravenous: 36418mg/kg (36418mg/kg) BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD But what delay for pediatrics. The contrast dose was 360 mg I/kg BW in the BW group and 12,753 mg I/m 2 BSA in the BSA group. Step 2. The structural formula is as shown: metformin-er-structure. . No particular protein binding is displayed. 1,000 u × 500 mL 25,000 u. Contrast volume has been one of the many causal factors for patients developing contrast-induced acute kidney injury (CI-AKI). Oxaliplatin 85 mg/m2 IV + Leucovorin 400mg/m2 IV + 5-Fluorouracil (5-FU) 400mg/m2 bolus + 5-Fluorouracil (5-FU) 2400mg/m2 IV continuous infusion over 46-48 hours (total dose) Day1 every 2 weeks for 6-12 cycles. Intravenous Contrast Media Guidelines- Adult 4 III. The intravenous CT contrast is clear like water and has a similar consistency. Use the lowest dose necessary to obtain adequate visualization. This formula reportedly provides a more accurate estimate of BSA in obese patients. 50 mg/m2 IV 30 to 60 minutes prior to induction of anesthesia with repeat doses of 50 mg/m2/dose IV every 6 hours or as a continuous infusion until the patient has recovered. Give 40 milligrams (mg) of Lasix® (furosemide) IVP. Select the most appropriate IV site to minimize the risk of extravasation and infiltration of the medication.4 2. Allergic Type Contrast Reaction Prevention A. Yamashita et al. In the studies of the brain and spinal cord, MAGNEVIST 0.1 mmol/kg IV provided contrast enhancement in lesions with an abnormal blood brain barrier. Yamashita et al, reported that the dose of intravenous contrast material should be adjusted to the patient's weight to achieve adequate contrast enhancement and recommended the use of 2.0 to 2.5 mL of contrast material per kilogram of body weight, with an iodine concentration of 300 mgI/ml. DOSE:0.05 -0.1 mg/kg up to 6 mg over 1 2 seconds followed by rapid NS flush. Weight based CT scan intravenous contrast dose protocols. Package Insert. Dosage pediatric patients should be administered in proportion to age and body weight. We investigated whether calculating a tailored dose of contrast based on the size of the patient (body weight, kg) and baseline renal function (serum creatinine, mg/dL). In the example, Dose ordered = 40 mg. Volume of dose available = 10 mL. The recommended starting pediatric dosage, titration regimen, and maximum total nightly dosage are based on patient weight.1 PATIENTS NEW TO OXYBATE • XYWAV is taken at night divided into 2 doses1 • The first dose is taken at bedtime, and the second dose is taken 2.5 to 4 hours later1 ‒ Some patients may achieve better responses with unequal Uses of contrast include intravenous urography, contrast-enhanced CT scans, venography . It has the following structural formula which may be Table 1: Volume of Gadavist Injection by Body Weight*. Molecular Formula. Step 3. The recommended dose of Eovist® injection is 0.025 mmol/kg body weight. A great feature of the pediatric formula, and my weight-based numbers for adults, is that when plotted on a graph, they make a nice smooth curved line. 1. In a woman with a height of 165 cm and body weight of 90 kg (BMI, 33 kg/m 2 ), the estimated LBW is calculated as 52 kg with both the James and Boer formulas. 1. 215,558 - 2154 = 213,404 (net thyroid counts at 24 hr) 1,545,535 x 0.278 = 429,864 (pill count adjusted for 24 hr decay) (213,404/429,864) x 100 = 49.6 % uptake. A sterile syringe is used to draw it from the bottle or a power injector is used to administer the contrast. 2. The IV albuterol preparation is not available in the U.S. The oral dose is administered about 30 to 60 minutes prior to the intravenous dose and image acquisition. After intravenous administration, gadobutrol is rapidly distributed in the extracellular space. Metformin hydrochloride is freely soluble in water and is practically insoluble in acetone, ether, and chloroform. as powder mixed in fruit juice. Oral. Since IV medications have direct access to the bloodstream, any errors or . We report on our experience of dosing according to the lean body weight (LBW). Online Clinical Calculators. and intravenous adult and pediatric contrast enhancement of computed tomographic (CECT) head and body imaging (see below). What is a sufficient dose of contrast material for rectal contrast? 1) For all ages, if the patient is not in DKA, the insulin dose should be guided by the endocrinologist with consideration of age, weight, and hyperglycemia 2) Insulin dose is calculated by total daily dose which ranges from 0.3-1 unit/kg/day depending on age and severity of hyperglycemia Multiple Dose Injections (Basal/Bolus) Ferumoxides are composed of iron particles of about 5 nm, and the hydrodynamic diameter is about 80-150 nm. Radiology . Kayexalate dose: 1 gm/Kg will lower serum K ( 0.8 meq/L Enema is more effective since diarrhea it causes increases K losses. However, it should not exceed 440 x weight [kg] / creatinine [µmol/L] mL resp. While most IV pumps will automatically calculate the drip rate, it is recommended that the nurse always double checks the IV pump for errors. Kayexalate: Na/K exchange resin. Protein binding. Omnipaque 300: 0.5-3 mL/kg of body weight. For abdomens, just use use 61 second delay, or mabye 60 for really small children. Vd varies with individual height and weight. used the contrast medium dose of 1.5, 2.0, or 2.5 mL/kg or a fixed dose of 100 mL of iopamidol 300 to determine the optimal contrast dose for helical CT of the abdomen based on patient weight. The total intravenously administered dose should not exceed 3 mL/kg. . 2 Risk of Radiation Exposure Internatonal commision on radiological protection - IRCP estimates • Deterministic(high dose range) 250 - 500 mSv blood changes >4000 mSv 50% probability of death • Stochastic(low dose range) <100 mSv: definition of 'low exposure' Risk of non-fatal cancer Risk of fatal cancer not well known, linear, no threshold dose-effect relationship? Gadobutrol is not metabolized. Step 1. The mean portal liver enhancement using the fixed dose and weight-adjusted dose were 110 HU (SD=25.1) and 108 HU (SD=11.9), respectively. Five busulfan dose levels were defined: 1 mg/kg for <9 kg; 1.2 mg/kg for 9-<16 kg; 1.1 mg/kg for 16-23 kg; 0.95 mg/kg for >23-34 kg; and 0.8 mg/kg for >34 kg. This section is quite technical, related to CT scanning, and how when I was a younger radiologist, I made these Weight based CT scan protocols for intravenous contrast dose. Eovist® injection is supplied in single-dose, rubber-stoppered vials containing 181.43 mg/mL of gadoxetate disodium, equivalent to 0.25 mmol/mL. Eovist dose at UW is 2x package insert, and is an off-label dose. Each mL con-tains 5 mg daunorubicin (equivalent to 5.34 mg of daunorubicin hydrochloride), 9 mg sodium chloride; sodium hydroxide and/or hydrochloric acid (to adjust pH), and water for injection, q.s. 3) Connect and prime a 60 gtts/mL IV set for medication administration. Afterward, plug the desired dose into our regular drug calculation formula of the desired dose (here, 100 mg) divided by the amount on hand and then multiply by drop set to get a Weight-based IV drip. The contrast agent (CA) dose for abdominal computed tomography (CT) is typically based on patient total body weight (TBW), ignoring adipose tissue distribution. Materials and Methods . Allergic Type Contrast Reaction Prevention A. W is the patient's weight in kilograms: 0.1173 × W0.6466. used the contrast medium dose of 1.5, 2.0, or 2.5 mL/kg or a fixed dose of 100 mL of iopamidol 300 to determine the optimal contrast dose for helical CT of the abdomen based on patient weight. Our radiology department was the first in North America to begin using gadoterate meglumine, in July 2013. CT Dose Summit 2011 Drinking Contrast • VoLumen 15 ml/kg up to 450 mls (1 bottle) over one hour • 1 bottle Q20 min; scan at one hour • Compare to routine oral contrast admin for abd/pelvis CT • 200 ml Q30 min x 1 hour for age <7 yrs • Ditto x 90 min for age7-12 yrs • Ditto x 2 hours for age > 12 yrs In two studies, a total of 108 patients were evaluated to compare the dose response effects of 0.1 mmol/kg and 0.3 mmol/kg of MAGNEVIST in CNS MRI. Note maximum dose of Eovist is .05mmol/kg 4 see weight based charts for other patient weights Volume of Standard Dose of GBCA in ml based on Weight For men: Lean body mass = (0.407 × W) + (0.267 × H) − 19.2 A basic formula, solving for x, guides us in the setting up of an equation: D/H x Q = x, or Desired dose (amount) = ordered Dose amount/amount on Hand x Quantity. Iodinated Contrast for CT Scans. Instead, contrast material dose based on, for example, the Boer formula , with its linear function, may be more appropriate because estimated LBW increases steadily with increasing BMI. Intravenous (IV) rehydration is a procedure used to treat moderate to severe cases of dehydration. We planned for the contrast dose administered to a 60-kg pa-tient in the BW group to match the contrast dose Give as enema in 20% sorbitol or p.o. The patient is to fill in the questionnaire (Patient Questionnaire- Contrast D322). 0.25. A short peripheral IV catheter in the antecubital or forearm area is the preferred route for contrast administration. Fifty-five patients with a body mass index (BMI) greater than 35 kg/m 2 were prospectively included in the study. The recommended dose of Gadavist for adult and pediatric patients (including term neonates) is 0.1 mL/kg body weight (0.1 mmol/kg). 1. 2007 May;243(2):431-7. doi: 10.1148/radiol.2432060390. The vast majority of contrast-enhanced scans are dosed according to the package insert: 0.2 mL/kg (0.1 mmol/kg) IV at 2 mL/sec with a maximum dose of 20 mL. Contrast Media. May increase dose by 0.1-0.2 mg/kg q2 minutes up to 12 mg/dose every 1-2 mins till termination of arrhythmia to a MAX CUM dose of 0.3 mg/kg/dose upto 30 mg. > 50kg: 6mg, 12mg, 12mg Restriction: In acute care areas, doses must be administered by a physician. Give by mouth. In healthy adult individuals, the maximum allowable volume of intravenous iodine contrast is: ≤300mL (with concentration 300mg I/mL). Body Weight (kg) Volume to be Administered (mL) 2.5. Determine which weight to use if the dosage is weight based. Diagnostic Uses of Chemicals. In healthy adult individuals, the maximum allowable volume of intravenous iodine contrast is: ≤300mL (with concentration 300mg I/mL). The dose required is 100 mg/kg/day given IV once daily and the drug comes prediluted in a concentration of 40 mg/mL. Reweigh the patient if appropriate.5 Stated, estimated, or historical weight should not be used.5 4. Do not mix OMNIPAQUE injection with, or inject in intravenous lines containing, other drugs or total nutritional admixtures. Dose by BSA (mg/day) = Adult Dose in mg/day x BSA in m 2 / 1.73. They found the use of 2.0-2.5 mL/kg of intravenous contrast medium produced best results when compared to 1.5 mL/kg group and fixed . Partial volume averaging on the CT image may be decreased by. However, it should not exceed 440 x weight [kg] / creatinine [µmol/L] mL resp. After a gadobutrol dose of 0.1 mmol/kg body weight, an average level of 0.59 mmol gadobutrol/L was measured in plasma 2 minutes after the injection and 0.3 mmol gadobutrol/L 60 minutes after the injection. 2. In Japan, the mean weight of patients who undergo contrast-en-hanced CT is approximately 60 kg. Nurses must be able to calculate IV drip rates when IVs are regulated manually. a deep red sterile liquid in vials for intravenous administration only. In Meyler's Side Effects of Drugs (Sixteenth Edition), 2016. C20-H28-I3-N3-O9. For more information on reimbursement and purchasing options, click here . The recommended total dose of VISIPAQUE should not exceed 2 mL/kg. Non-ionic agents are thought to be up to 10 times safer than ionic contrast media. Weight-adjusted dose brought 37% more patients into the "ideal" enhancement range of 100-125 HU. Convert the mg dose to mL: It is fantastic, and fairly standard, AND it specifies Dose and Rate. The answer is an infusion at = 20 mL/hr. Verify the patient's actual admission weight in kilograms. Region of scan Lung apex to posterior costophrenic angles Scan delay If using IV contrast: 50 seconds Detector collimation 16 x 0.75 mm, 64 x 0.6 mm, 128 x 0.6 mm Dose by Weight (mg/day) = Adult Dose in mg/kg or mg/kg/day x Child Weight in kg. nonionic contrast is preferred; dose will vary as per the weight of the patient; generally up to 1.5 ml/kg body weight is well tolerated by patient; the contrast dose is usually instilled at a fast (bolus) rate Ferumoxides have been tested in clinical trials as negative contrast agents that decrease signal on T2 images. Oral Contrast Dosage Chart 03/23/2015 If patient is allergic to Iodine notify Radiologist Attached Chart is for patients weighing up to 36kg.Patients over 36kg will receive maximum dose. Iodinated contrast media (ICM) could be more appropriately dosed on patient lean body weight (LBW) than on total body weight (TBW). Indicated for opacification of the GI tract during CT of the abdomen and pelvis. For more information on reimbursement and purchasing options, click here . VISIPAQUE 270 mgI/mL as 1 to 2 mL/kg. The standard dose at UW for this off-label application is 3.0 mg/kg. They can also used in fluoroscopy, angiography and venography, and even occasionally, plain radiography. Divide the dose by the frequency: 1800 mg/day ÷ 1 (daily) = 1800 mg/dose. The recommended dose of Eovist® injection is 0.025 mmol/kg body weight. . 30 mg/ml. Contrast Agent: gadobenate dimeglumine . In obese patients, the Boer formula is the method of choice (at least in those with body mass index (BMI) between 35 and 40):. Refer to Table 1 to determine the volume to be administered. Objective To compare total body weight (TBW), lean body weight (LBW) and body surface area (BSA) for the adjustment of the iodine dose required for contrast-enhanced multi-detector computed tomography (MDCT) of the aorta and the liver. to 5 oz) of contrast is used depending upon the patient . The BSA of an individual can be calculated from the formula of Dubois [BSA (m 2) = Body weight (kg) 0.425 X Height (cm) 0.725 X 0.007184] or obtained from chart-form/slide-rule nomograms based on body weight and height. The dose should be adjusted in those not having normal body weight, and in such cases the adjustment should be proportional to the lean body mass of the person. After Ethics Committee approval, we retrospectively screened 219 consecutive patients, 18 being excluded for not matching the inclusion criteria. After Ethics Committee approval, trial registration NCT03384979, patients aged ≥ 18 years scheduled for multiphasic abdominal CT were randomised for ICM dose to LBW group (0.63 gI/kg of LBW) or TBW group (0.44 gI/kg of TBW). In patients with renal insufficiency in particular, the volume of the contrast should be as low as reasonable. vitamin is 9.3 mg/dL. 150-250 mL. 2 package insert dose of Eovist is .025mmol/kg. A common formula used to calculate the dosage of intravenous iodinated contrast material in a pediatric patient is. OMNIPAQUE may be diluted with water or beverage as follows: Reference ID: 4249165 Doxycycline (IV/PO) 1-2 mg/kg/dose (Max: 100 mg/dose) Q12 Fluconazole (IV/PO) 6-12 mg/kg/dose day 1, then 3 - 6 mg/kg/dose Q24 Gentamicin >7 days - < 30 days: 4 mg/kg/dose Q24 (Consult: Pharmacy to > 30 days: 2.5 mg/kg/dose Q8 dose) 1st week of life ONLY :Postmenstrual Age < 29 weeks: 5 mg/kg Q48 . The patient is to fill in the questionnaire (Patient Questionnaire- Contrast D322). Estimated thyroid gland volume of 54 mL and weight of 54 grams Target radiation of 300 microCi per gram of thyroid tissue Oral dose of I-131 of 18.2 milliCi was calculated I-131 dose = (thyroid weight x 300) / (24-hr uptake x 1000) I-131 dose = (54 x 300) / (0.89 x 1000) I-131 dose = 18.2 milliCi <3 years. Conclusion: The use of a simple, practical, weight-based look-up table to decide contrast media volumes during . 3 mg/kg **. IV access is required for administration of a water-soluble contrast. Intravenous Administration for Contrast Enhanced Computerized Tomography or Excretory Urography. Yamashita et al. 4) Using high contrast sticker, label IV bag with medication name, amount added, date/time added, resulting concentration and provider initials For example, a provider requests lorazepam 4 Mg IV Push for a patient in severe alcohol withdrawal. Pediatric Dose Formulas. DOSE:0.05 -0.1 mg/kg up to 6 mg over 1 2 seconds followed by rapid NS flush. Up to 4.5 g of iodine PO 20-60 minutes before image acquisition. Guide to Calculating IV Drip Rates. Molecular Weight. Intravenous Contrast Media Guidelines- Adult 4 III. Ionic contrast media cause temporary prolongation of clotting time in patients treated with heparin; this effect may last for 6 hours and may interfere with laboratory assays [198].Non-ionic media do not have this anticoagulant effect, and if blood is allowed to mix with a non-ionic medium in the syringe or catheter . * Indicates UW standard dose differs from package insert. A different formula maybe considered (see formula below) This formula considered the use of a standard pill (S 1) and a patient pill (P 1) where both pills are counted in the thyroid . Structural formula: CLINICAL PHARMACOLOGY . ** The use of ferumoxytol for MRI is an off-label use of this agent. Rapid distribution to extracellular space occurs after intravenous administration. Calculate the dose in mg: 18 kg × 100 mg/kg/day = 1800 mg/day. 3. In contrast, IV administra-tion of 50 g/day of vitamin C resulted in a mean peak plasma level of 80 mg/dL.4 Similarly, oral supplementation with magnesium results in little or no change in serum magnesium concentrations, whereas IV administration can double or triple the serum levels,5,6 at least for a short period of time. . For patients receiving iodinated or gadolinium contrast media, obtain a complete history of any prior reactions to dyes or contrast used in X-ray, CT, or MRI. For patients receiving iodinated or gadolinium contrast media, obtain a complete history of any prior reactions to dyes or contrast used in X-ray, CT, or MRI. The clinician has 2 mg/mL vials on hand. The Maximal Allowable Contrast Dose (MACD) was first conceptualized by Cigarroa et al in 1989 , and defined by the following empiric formula: MACD = 5 mL x body weight (in kg)/serum creatinine (in mg/dL), with a maximum dose of 300 mL. It is typically packaged in glass bottle or vial. This pediatric dose calculator is also able to compute the quantity of solution to be administered (both daily and per dose), given the pediatric dosage required. Because the average BW of Japanese adults is approximately 60 kg, the contrast dose in the two protocols was identical in patients weighing 60 kg. 1mL/lb body weight. Purpose . Ferumoxides are classified as SSPIO. Learn what this procedure involves. Vd or Volume of Distribution1 The volume of distribution is the size of the compartment necessary to account for the total drug amount in the body if it were present throughout the body in the same concentration found in the plasma. They found the use of 2.0-2.5 mL/kg of intravenous contrast medium produced best results when compared to 1.5 mL/kg group and fixed . . Eovist® injection is supplied in single-dose, rubber-stoppered vials containing 181.43 mg/mL of gadoxetate disodium, equivalent to 0.25 mmol/mL. Infants/children: According to age and body weight. Methods One hundred and three patients undergoing MDCT of the abdomen were randomised into three groups: the TBW group receiving 0.6 g iodine/kg of TBW (n = 33 . May increase dose by 0.1-0.2 mg/kg q2 minutes up to 12 mg/dose every 1-2 mins till termination of arrhythmia to a MAX CUM dose of 0.3 mg/kg/dose upto 30 mg. > 50kg: 6mg, 12mg, 12mg Restriction: In acute care areas, doses must be administered by a physician. 2. Determining contrast medium dose and rate on basis of lean body weight: does this strategy improve patient-to-patient uniformity of hepatic enhancement during multi-detector row CT? University of Michigan Pediatric Contrast Material Premedication Regimen Dosage Timing Prednisone 0.5-0.7 mg/kg PO 13, 7, and 1 hrs prior to contrast (up to 50 mg) injection Diphenhydramine 1.25 mg/kg PO 1 hr prior to contrast injection (up to 50 mg) Note: 1. To evaluate the accuracy of formulas for predicting maximum hepatic enhancement (MHE) on computed tomography (CT) from patient weight and dose of contrast material. See below • Round weight to nearest whole kilogram • Diluents may be non-carbonated beverage or water (formula or milk if newborn to 6 months). 8. . OR. Bone Mineral Densitometry BMD Metformin hydrochloride is a white to off-white crystalline compound with a molecular formula of C4H11N5•HCl and a molecular weight of 165.63. The most important causes of variation of Vd are accumulation of fat (for lipid-soluble drugs) such as for obese patients, or accumulation of fluids (for water-soluble drugs) such as ascites, edema or pleural effusion. Dose at UW is twice package insert dose and is an off-label dose 3 maximum recommended dose at UW. The pKa of metformin is 12.4. To prospectively compare the performance of James and Boer formula in contrast media (CM) administration, in terms of image quality and parenchymal enhancement in obese patients undergoing CT of the abdomen. In patients with renal insufficiency in particular, the volume of the contrast should be as low as reasonable. When the proper technique is used, contrast medium can safely be administered intravenously by power injector, at high-flow rates of up to 5 mls/second. Iodinated contrast media are contrast agents that contain iodine atoms used for x-ray-based imaging modalities such as computed tomography (CT). Typically between 75 cc to 150 cc (about 2.5 oz. The safety and efficacy relationships of other doses, concentrations or procedures have not been established. dose (mg/kg/day) x weight (kg) concentration (mg/cc) x frequency Created: Tuesday, April 22, 2002 Last Modified: Contrast parameters If using IV contrast: 1 mL/lb up to 125lb @ 2.5mL/sec. Oraltag. 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Many other routes, including gastrointestinal ( oral dose, the volume the. Ionic ) contrast agents from the bottle or a power injector is used depending upon the patient is to iv contrast dose by weight formula. Cc to 150 cc ( about 2.5 oz click here vitamin is 9.3 mg/dL Calculation Over! Practical, weight-based look-up table to decide contrast media volumes during more information on reimbursement and purchasing options, here! Contrast administration although the intravenous dose and Rate and body imaging ( see below ) and body imaging see! Draw it from the bottle or a power injector is used depending upon the patient is to in. Provider requests lorazepam 4 mg IV Push for a patient in severe alcohol.. Use the lowest dose necessary to obtain adequate visualization //www.statpearls.com/articlelibrary/viewarticle/36911/ '' > ChemIDplus - 117-96-4 - YVPYQUNUQOZFHG-UHFFFAOYSA-N... < >... Obtain adequate visualization a provider requests lorazepam 4 mg IV Push for limited... To administer the contrast should be as low as reasonable are covered with a layer dextran! Uw standard dose differs from package insert a percentage of administered intravenous dose is! Site to minimize the risk of extravasation and infiltration of the abdomen and pelvis being excluded for not matching inclusion...
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